Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "New methodology for specific inhalation challenges with occupational agents. | Caron et al. Respiratory Research 2010 11 72 http content 11 1 72 RESPIRATORY RESEARCH RESEARCH Open Access New methodology for specific inhalation challenges with occupational agents Simon Caron1 Jean-Christian Boileau1 Jean-Luc Malo 2 and Simon Leblond1 Abstract Background Inhalation challenges are used for diagnosing occupational asthma OA . The initial methodology consisted of a realistic exposure without monitoring nor controlling exposure. Our aim was to design an equipment called the GenaSIC that allows the generation of various agents regardless of the formulation and to assess the feasibility of its use in patients investigated for OA. Results GenaSIC can generate lactose flour malt isocyanates formaldehyde and N-butyl acetate with precise and fairly stable concentrations. Using N-butyl-acetate as a control agent and real time measurement we show that normal breathing has a negligible effect on the concentration. We exposed forty-four different subjects to a control agent and or to a suspected occupational agent. Nineteen of the subjects were only exposed to N-butyl acetate as a control agent without experiencing any significant irritant effect no significant changes in spirometry thereafter . Eight subjects who were exposed to both N-butyl acetate and formaldehyde did not show significant reactions. Seven subjects were exposed to dry particles flour in six instances malt in the other and five showed immediate asthmatic reactions which changes in FEV1 from 20 to a maximum of 28 . Finally ten subjects were exposed to isocyanates four of whom showed a positive reaction including one subject with immediate maximum changes in FEV1 of 22 . Conclusion GenaSIC offers the possibility of reliable and safe exposures to dry particles formaldehyde and isocyanates in the investigation of OA. Introduction Occupational asthma OA is a type of asthma caused by the workplace. The most common type of OA is the one that occurs after a latency period .
