Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation. | Flynn et al. Respiratory Research 2010 11 117 http content 11 1 117 RESPIRATORY RESEARCH RESEARCH Open Access Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation 13 111 2 Gordon Flynn Gerlinde Mandersloot Marie Healy Mark Saville Daniel F McAuley Abstract Background Prolonged weaning from mechanical ventilation has a major impact on ICU bed occupancy and patient outcome and has significant cost implications. There is evidence in patients around the period of extubation that helium-oxygen leads to a reduction in the work of breathing. Therefore breathing helium-oxygen during weaning may be a useful adjunct to facilitate weaning. We hypothesised that breathing helium-oxygen would reduce carbon dioxide production during the weaning phase of mechanical ventilation. Materials patients and methods We performed a prospective randomised controlled single blinded cross-over trial on 19 adult intensive care patients without significant airways disease who fulfilled criteria for weaning with CPAP. Patients were randomised to helium-oxygen and air-oxygen delivered during a 2 hour period of CPAP ventilation. Carbon dioxide production VCO2 was measured using a near patient main stream infrared carbon dioxide sensor and fixed orifice pneumotachograph. Results Compared to air-oxygen helium-oxygen significantly decreased VCO2 production at the end of the 2 hour period of CPAP ventilation there was a mean difference in CO2 production of ml min 95 CI p between the groups. There were no significant differences in other respiratory and haemodynamic parameters. Conclusion This study shows that breathing a helium-oxygen mixture during weaning reduces carbon dioxide production. This physiological study supports the need for a clinical trial of helium-oxygen mixture during the weaning phase of mechanical ventilation with duration of weaning as the primary outcome. Trial registration ISRCTN56470948 .
