Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis. | Available online http content 11 6 R195 Research article Active immunization to tumor necrosis factor-a is effective in treating chronic established inflammatory disease a long-term study in a transgenic model of arthritis Laure Delavallée1 Luca Semerano1 2 Eric Assier1 Géraldine Vogel3 Grégoire Vuagniaux4 Marion Laborie3 Daniel Zagury3 Natacha Bessis1 and Marie-Christophe Boissier1 2 1EA4222 Li2P University of Paris 13 74 rue Marcel Cachin 93000 Bobigny France 2Rheumatology Department Hôpital Avicenne Assistance Publique-Hôpitaux de Paris AP-HP 1 25 rue de Stalingrad 93000 Bobigny France 3Neovacs SA 3-4 impasse Reille 75014 Paris France 4Debiopharm SA Chemin Messidor 5-7 Case Postale 5911 CH-1002 Lausanne Switzerland Corresponding author Marie-Christophe Boissier boissier@ Received 20 Oct 2009 Revisions requested 2 Dec 2009 Revisions received 11 Dec 2009 Accepted 23 Dec 2009 Published 23 Dec 2009 Arthritis Research Therapy 2009 11 R195 doi 86 ar2897 This article is online at http content 11 6 R195 2009 Delavallée et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Passive blockade of tumor necrosis factor-alpha TNF-a has demonstrated high therapeutic efficiency in chronic inflammatory diseases such as rheumatoid arthritis although some concerns remain such as occurrence of resistance and high cost. These limitations prompted investigations of an alternative strategy to target TNF-a. This study sought to demonstrate a long-lasting therapeutic effect on established arthritis of an active immunotherapy to human h TNF-a and to evaluate the long-term consequences of an endogenous anti-TNF-a response. Methods hTNF-a transgenic
