Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: When rheumatology meets hepatology: are anti-TNFs safe in hepatitis B virus carriers? | Jansen Arthritis Research Therapy 2010 12 103 http content 12 1 103 EDITORIAL L_ When rheumatology meets hepatology are anti-TNFs safe in hepatitis B virus carriers Tim L Jansen See related research by Charpin etal. http content 11 6 R179 Abstract Over the past decades more effective and less toxic biologicals have revolutionized rheumatology therapy in our battle against the autoimmune chronic inflammation of rheumatoid arthritis and spondyloarthropathy. But what about for patients who have previously had an infection of the liver Prior hepatitis B virus infection clearly presents a challenge for clinicians. In a study by Charpin and colleagues of 21 patients whose hepatitis B virus serology suggested carrier status anti-TNF treatment appeared to be safe during a limited follow-up period of 3 years. Studies are needed with longer follow-up particularly in patients with low antibody titres antiHBc . In the 3-year period however about 30 of the patients developed significant lowering of antibody titres which may become relevant during long-term follow-up. Charpin and colleagues are the first to reveal promising data on the relative safety of anti-TNFs in a small series of hepatitis B carriers for up to 3 years. In the previous issue of Arthritis Research Therapy Charpin and colleagues present French results from an interesting cohort of 21 hepatitis B virus HBV carriers with active rheumatoid arthritis or spondyloarthropathy being treated with antibodies to TNF 1 . What do we know about anti-TNF therapy in patients who have recovered from HBV infection Hepatology has provided knowledge on HBV infection and antivirals have made hepatitis a potentially well-treatable disease since three decades ago 2 . For the past couple of decades monoclonal antibodies against TNF have been available Correspondence Department of Rheumatology Medical Centre Leeuwarden POB 888 89 34 AD Leeuwarden The Netherlands 2
