Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. | Zanini et al. Respiratory Research 2010 11 132 http content 11 1 132 RESPIRATORY RESEARCH REVIEW Open Access The role of the bronchial microvasculature in the airway remodelling in asthma and COPD A 7a niCli 1A fro clrahaffa2 Aoclro c Q Imrscrotrsrỉ3 A to Fes to les Crsoncx dllc 1 4 Fh .irio rallx lcrl2 Aliened Zdinin Alnedo ci lend Aliened S niipeidtuii Antonio spdnevello Ddrio Olivieri Abstract In recent yedrs there hds been incredsed interest in the vdsculdr component of dirwdy remodelling in chronic bronchidl infldmmdtion such ds dsthmd dnd COPD dnd in its role in the progression of disedse. In pdrticuldr the bronchidl mucosd in dsthmdtics is more vdsculdrised showing d higher number dnd dimension of vessels dnd vds-culdr dred. Recently insight hds been obtdined regdrding the pivotdl role of vdsculdr endothelidl growth fdctor VEGF in promoting vdsculdr remodelling dnd dngiogenesis. Mdny studies conducted on biopsies induced sputum or BAL hdve shown the involvement of VEGF dnd its receptors in the vdsculdr remodelling processes. Presumably the vdsculdr component of dirwdy remodelling is d complex multi-step phenomenon involving several medidtors. Among the common dsthmd dnd COPD medicdtions only inhdled corticosteroids hdve demonstrated d redl dbility to reverse dll dspects of vdsculdr remodelling. The dim of this review wds to dndlyze the morphologicdl dspects of the vdsculdr component of dirwdy remodelling dnd the possible mechdnisms involved in dsthmd dnd COPD. We dlso focused on the functiondl dnd therapeutic implicdtions of the bronchidl microvdsculdr chdnges in dsthmd dnd COPD. Introduction Bronchial vessels usually originate from the aorta or intercostal arteries entering the lung at the hilum branching at the mainstem bronchus to supply the lower trachea extrapulmonary airways and supporting structures. They cover the entire length of the bronchial tree as far as the terminal bronchioles where they anastomose with the pulmonary .
