Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Levels of anti-citrullinated protein antibodies and IgM rheumatoid factor are not associated with outcome in early arthritis patients: a cohort study. | Ursum et al. Arthritis Research Therapy 2010 12 R8 http content 12 1 R8 RESEARCH ARTICLE Open Access Levelslof anti-citrullinated protein antibodies and IgM rheumatoid factor are not associated with outcome in early arthritis patients a cohort study Jennie Ursum 1 Wouter H Bos1 Nancy van Dillen1 Ben AC Dijkmans1 2 and Dirkjan van Schaardenburg 1 2 Abstract Introduction To investigate whether baseline levels of anti-citrullinated protein antibody ACPA or IgM rheumatoid factor IgM-RF and changes in the year thereafter are associated with disease activity functional and radiographic outcome in early arthritis patients and provide additional information over baseline autoantibody status. Methods In 545 early arthritis patients ACPA and IgM-RF levels disease activity DAS28 the Health Assessment Questionnaire HAQ and Sharp Van der Heijde Score SHS were assessed annually. Baseline status levels and first-year changes of the autoantibodies were associated with these measures at the two-year follow-up and sub-analysed according to autoantibody status. Results The mean age was years 69 was female at baseline 56 was ACPA positive 47 IgM-RF positive. At the two-year follow-up the mean DAS28 was and the median HAQ and SHS were and 1 respectively. At one year ACPA and IgM-RF levels had decreased by 31 and 56 respectively. A switch from negative to positive occurred in 2 for ACPA and 3 for IgM-RF. Positive ACPA and RF status were both associated with SHS at two years P but baseline levels only showed a minor correlation of ACPA with DAS28 and HAQ at two years. Level changes were not associated with the outcome parameters. Conclusions Baseline levels and first-year changes of ACPA and IgM-RF are hardly associated with outcome after two years. Seroconversion seldom occurs. Therefore it does not appear useful to repeat ACPA or IgM-RF measurements. Introduction Rheumatoid arthritis RA is often accompanied by autoimmune phenomena notably .
