Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study. | Davies-Tuck et al. Arthritis Research Therapy 2010 12 R10 http content 12 1 R10 RESEARCH ARTICLE Open Access Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis a longitudinal study Miranda L Davies-Tuck 1 Anita E Wluka1 2 Andrew Forbes1 Yuanyuan Wang1 Dallas R English3 4 Graham G Giles3 Richard O Sullivan5 and Flavia M Cicuttini 1 Abstract Introduction To examine the relationship between development or resolution of bone marrow lesions BMLs and knee cartilage properties in a 2 year prospective study of asymptomatic middle-aged adults. Methods 271 adults recruited from the Melbourne Collaborative Cohort Study underwent a magnetic resonance imaging scan MRI of their dominant knee at baseline and again approximately 2 years later. Cartilage volume cartilage defects and BMLs were determined at both time points. Results Among 234 subjects free of BMLs at baseline 33 developed BMLs over 2 years. The incidence of BMLs was associated with progression of tibiofemoral cartilage defects OR 95 CI P for medial compartment OR 95 CI P for lateral compartment . Among 37 subjects with BMLs at baseline 17 resolved. Resolution of BMLs was associated with reduced annual loss of medial tibial cartilage volume regression coefficient 95 CI -65 P and a trend for reduced progression of medial tibiofemoral cartilage defects OR 95 CI P . Conclusions In this cohort study of asymptomatic middle-aged adults the development of new BMLs was associated with progressive knee cartilage pathology while resolution of BMLs prevalent at baseline was associated with reduced progression of cartilage pathology. Further work examining the relationship between changes and BML and cartilage may provide another important target for the prevention of knee osteoarthritis.
