Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells? | Wilde et al. Arthritis Research Therapy 2010 12 204 http content 12 1 204 REVIEW T cells in ANCA-associated vasculitis what can we learn from lesional versus circulating T cells Benjamin Wilde1 2 Marielle Thewissen1 Jan Damoiseaux1 Pieter van Paassen1 Oliver Witzke2 and Jan Willem Cohen Tervaert 1 Abstract Anti-neutrophil cytoplasmic antibody ANCA -associated vasculitis AAV is a life-threatening autoimmune disease characterized by an antibody-mediated glomerulonephritis and necrotizing vasculitis. Apart from antibodies T cells are also involved in disease pathogenesis. This review stresses the hallmarks of T cell-mediated pathology in AAV and highlights the characteristics of lesional and circulating T cells in the immune response in AAV. Circulating effector T-cell populations are expanded and are in a persistent state of activation. Circulating regulatory T-cell subsets are less well characterized but seem to be impaired in function. Lesional effector T cells are present in granulomas vasculitic lesions and nephritis. Lesional T cells usually show pro-inflammatory properties and promote granuloma formation. Apart from T cells dendritic cells are abundantly present at the sites of inflammation and locally orchestrate the immune response. Targeting the above-mentioned T cell-mediated disease mechanisms will potentially provide powerful therapeutic tools for AAV. Introduction Anti-neutrophil cytoplasmic antibody ANCA -associa-ted vasculitis AAV is a life-threatening form of autoimmune small-vessel vasculitis. AAV comprises three similar disease entities Churg-Strauss syndrome CSS microscopic polyangiitis MPA and Wegener s granulomatosis WG . These three entities have the presence of ANCA in common. CSS and MPA patients usually have ANCA directed to myeloperoxidase MPO whereas in Correspondence secretariaat-immuno@ department of Internal Medicine Division of Clinical and Experimental Immunology University Hospital Maastricht .
