Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The role of leptin in the respiratory system: an overview. | Malli et al. Respiratory Research 2010 11 152 http content 11 1 152 RESPIRATORY RESEARCH REVIEW Open Access The role of leptin in the respiratory system an overview Foteini Malli Andriana I Papaioannou Konstantinos I Gourgoulianis Zoe Daniil Abstract Since its cloning in 1994 leptin has emerged in the literature as a pleiotropic hormone whose actions extend from immune system homeostasis to reproduction and angiogenesis. Recent investigations have identified the lung as a leptin responsive and producing organ while extensive research has been published concerning the role of leptin in the respiratory system. Animal studies have provided evidence indicating that leptin is a stimulant of ventilation whereas researchers have proposed an important role for leptin in lung maturation and development. Studies further suggest a significant impact of leptin on specific respiratory diseases including obstructive sleep apnoea-hypopnoea syndrome asthma COPD and lung cancer. However as new investigations are under way the picture is becoming more complex. The scope of this review is to decode the existing data concerning the actions of leptin in the lung and provide a detailed description of leptin s involvement in the most common disorders of the respiratory system. Introduction In the past years a growing number of studies have examined the potential role of leptin in the respiratory system. Accumulative data have identified foetal and adult lung tissue as leptin responsive and producing organs while leptin s involvement in pulmonary homeostasis has become increasingly evident Table 1 . On the basis of this conception researchers have sought to determine the impact of leptin on specific respiratory disorders including obstructive sleep apnoea-hypopnoea syndrome OSAHS asthma chronic obstructive pulmonary disease COPD and lung cancer. We review herein the current understanding on the actions of leptin in the lung and summarize the recent advances on its
