Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass. | Ibanez et al. Arthritis Research Therapy 2010 12 R50 http content 12 2 R50 RESEARCH ARTICLE Open Access A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass 12 2 2 3 2 Monica Ibanez Ana M Ortiz Isabel Castrejon J Alberto García-Vadillo Inmaculada Carvajal Santos Castaneda Isidoro González-Álvaro 2 Abstract Introduction Glucocorticoid GC -induced osteoporosis is a frequent complication in patients with rheumatoid arthritis. However little information exists about the consequences of GC use in patients with early arthritis. Here we describe the variables underlying the use of GC in early arthritis as well as its effect on bone-mineral density. Methods Data from 116 patients in our early arthritis register were analyzed 90 women median age years interquartile range IQR 6-month median disease duration at entry IQR 4-9 . In this register the clinical and treatment information was recorded systematically including the cumulative GC dose. Lumbar spine hip and forearm bone-mineral density BMD measurements were performed at entry and after a 2-year follow-up. A multivariate analysis was performed to establish the variables associated with the use of GCs as well as those associated with variations in BMD. Results Of the patients with early arthritis studied 67 received GCs during the 2-year follow-up. GCs were more frequently prescribed to elderly patients those with higher basal disease activity and disability and patients with positive rheumatoid factor. When adjusted for these variables GCs were less frequently prescribed to female patients. The use of GCs was associated with an increase of BMD in the ultradistal region of the forearm although it induced a significant loss of BMD in the medial region of the forearm. No relevant effect of GC was noted on the BMD measured at other locations. Conclusions The frequent use of GCs as a bridge therapy in patients with early arthritis does not .
