Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. | Morgan et al. Arthritis Research Therapy 2010 12 R57 http content 12 2 R57 RESEARCH ARTICLE Open Access Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1 PTPN22 OLIG3 TNFAIP3 STAT4 and TRAF1 C5 in an inception cohort Ann W Morgan 1 James I Robinson1 Philip G Conaghan1 Stephen G Martin1 Elizabeth MA Hensor1 Michael D Morgan1 Lori Steiner2 Henry A Erlich2 Hock-Chye Gooi3 Anne Barton4 Jane Worthington4 Paul Emery1 for UKRAG Consortium and the YEAR Consortium Abstract Introduction This study investigated five confirmed rheumatoid arthritis RA susceptibility genes loci HLA-DRB1 PTPN22 STAT4 OLIG3 TNFAIP3 and TRAF1 C5 for association with susceptibility and severity in an inception cohort. Methods The magnitude of association for each genotype was assessed in 1 046 RA subjects from the Yorkshire Early RA cohort and in 5 968 healthy UK controls. Additional exploratory subanalyses were undertaken in subgroups defined by autoantibody status rheumatoid factor and anti-cyclic citrullinated peptide or disease severity baseline articular erosions Health Assessment Questionnaire HAQ score and swollen joint count SJC . Results In the total RA inception cohort the HLA-DRB1 shared epitope per-allele odds ratio OR trend P PTPN22 per-allele OR trend P OLIG3 TNFAIP3 locus per-allele OR trend P and TRAF1 C5 locus per-allele OR trend P were associated with RA. The magnitude of association for these loci was increased in those patients who were autoantibody-positive. PTPN22 was associated with autoantibody-negative RA per-allele OR trend P . There was no evidence of association between these five genetic loci and baseline erosions or SJC in the total RA cohort after adjustment for symptom duration. TRAF1 C5 was significantly associated with baseline HAQ however following adjustment for symptom duration P trend . Conclusions These findings support the mounting evidence that different genetic .
