Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study. | Tanamas et al. Arthritis Research Therapy 2010 12 R58 http content 12 2 R58 RESEARCH ARTICLE Open Access The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis a longitudinal study Stephanie KTanamas 1 Anita E Wluka1 Jean-Pierre Pelletier2 Johanne Martel-Pelletier2 Franpois Abram3 Yuanyuan Wang1 and Flavia M Cicuttini 1 Abstract Introduction To examine the natural history of subchondral bone cysts and to determine whether knee cartilage loss and risk of joint replacement is higher in knees with cysts compared with those with bone marrow lesions BMLs only or those with neither BMLs nor cysts. Methods The symptomatic knee in 132 subjects with knee osteoarthritis OA was imaged by using magnetic resonance imaging at baseline and 2 years later. Tibial cartilage volume subchondral bone cysts and BMLs were measured by using validated methods. Knee arthroplasty over a 4-year period was ascertained. Results Bone cysts were present in of subjects of whom also had BMLs. Over a 2-year period of subjects had cysts progress developed new cysts and had cysts regress. Bone cysts at baseline were associated with lower medial and lateral tibial cartilage volume compared with those with BMLs only or those with neither P for trend and respectively . Annual medial cartilage volume loss was greatest in those with bone cysts compared with those with BMLs only or those with neither and respectively P for trend . As the severity of bone abnormality in the medial compartment increased from no BMLs or cysts present to BMLs only to subchondral bone cysts present the risk of knee replacement was increased odds ratio 95 confidence interval CI to P . Conclusions When cysts are present cartilage loss and risk of knee replacement are higher than if only BMLs are present suggesting that cysts identify those most likely
