Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. | Balsa et al. Arthritis Research Therapy 2010 12 R62 http content 12 2 R62 RESEARCH ARTICLE Open Access Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor Alejandro Balsa 1 Arancha Cabezon2 Gisela Orozco3 Tatiana Cobo1 Eugenia Miranda-Carus1 Miguel Ángel López-Nevot4 José Luis Vicario5 Emilio Martín-Mola1 Javier Martín3 and Dora Pascual-Salcedo2 Abstract Introduction The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis RA and production of antibodies against citrullinated proteins ACPA and rheumatoid factor RF . Methods We studied 408 patients 235 with RA 173 non-RA and 269 controls. ACPA RF and HLA-DR typing were determined. Results We found an increased frequency of HLA DRB1 alleles with the shared epitope SE in ACPA-positive RA. Inversely HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA and a similar trend was found for HLA DR3. However these results could not be confirmed after stratification for the presence of the SE probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found. Conclusions HLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA. Introduction Rheumatoid arthritis RA is a complex autoimmune disease that develops from the combined effects of genetic and environmental factors. It is estimated that the herita-bility of RA
