Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin. | Usui et al. Arthritis Research Therapy 2010 12 R64 http content 12 2 R64 RESEARCH ARTICLE Open Access Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin Chie Usui 1 Kotaro Hatta1 Nagafumi Doi2 Atsushi Nakanishi3 Hiroyuki Nakamura4 Kusuki Nishioka5 and Heii Aral1 Abstract Introduction The aim of the present study was to determine the brain areas associated with fibromyalgia and whether pretreatment regional cerebral blood flow rCBF can predict response to gabapentin treatment. Methods A total of 29 women with fibromyalgia and 10 healthy women without pain matched for age were finally enrolled in the study. Technetium-99m ethyl cysteinate dimer single photon emission computed tomography 99mTc-ECD SPECT was performed in the fibromyalgia patients and controls. A voxel-by-voxel group analysis was performed using Statistic Parametric Mapping 5 SPM5 . After treatment with gabapentin 16 patients were considered responders with decrease in pain of greater than 50 as evaluated by visual analogue scale VAS . The remaining 13 patients were considered poor responders . Results We observed rCBF abnormalities compared to control subjects in fibromyalgia including hypoperfusion in the left culmen and hyperperfusion in the right precentral gyrus right posterior cingulate right superior occipital gyrus right cuneus left inferior parietal lobule right middle temporal gyrus left postcentral gyrus and left superior parietal lobule. Compared to responders poor responders exhibited hyperperfusion in the right middle temporal gyrus left middle frontal gyrus left superior frontal gyrus right postcentral gyrus right precuneus right cingulate left middle occipital gyrus and left declive. The right middle temporal gyrus left superior frontal gyrus right precuneus left middle occipital gyrus and left declive exhibited high positive likelihood ratios. Conclusions The present study revealed brain regions with .
