Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment. | Simon et al. Arthritis Research Therapy 2010 12 R67 http content 12 2 R67 RESEARCH ARTICLE Open Access Infections requiring hospitalization in the abatacept clinical development program an epidemiological assessment A AcHin n2 I f Tiillo3 Pr nHin4 5 PraHd if L l lry fa6 ẠIlicr if i r r t i ir r i7 leiesd A Jimun Joiidn Askling Didne Ldcdille Jdiiod ridnklin riedeiick vvolie Allison Covucci Samy Suissd8 Mdic c Hochbeig9 the Abdtdcept Epidemiology Study Gioup Abstract Introduction Pdtients with iheumdtoid dithiitis RA hdve dn inciedsed i lsk of infection dnd this i isk dppedis to be highei with dnti-TNF tumoi necrosis fdctoi dgents. We pooled ddtd from the cumuldtive dbdtdcept RA clinicdl development piogidm both double-blind dnd open-ldbel peiiods to estimdte the incidence idtes IRs of infections requiting hospitdlizdtion including pneumonid dnd opportunistic infections in compdiison with RA pdtients tiedted with non-biologic disedse-modifying dntiiheumdtic diugs DMARDs fiom several iefeience cohorts. Methods Infections iepoited in seven dbdtdcept clinicdl tiidls of RA pdtients double-blind dnd open-ldbel peiiods weie tdbuldted. Compdiisons weie mdde between the obseived IRs in dbdtdcept-tiedted pdtients dnd those in ovei 133 000 pdtients exposed to non-biologic DMARDs in six reference RA cohorts. Age- dnd sex-ddjusted IRs of infections requiting hospitdlizdtion including pneumonid most frequent hospitdl infection weie used to estimdte the expected IRs with dbdtdcept by the method of indirect ddjustment. Stdnddidized incidence ratios SIR dnd 95 CI weie cdlculdted compdiing incidence in the cumuldtive dbdtdcept expeiience with incidence in edch RA cohort. Results A totdl of 1 955 double-blind peiiod dnd 4 134 double-blind open-ldbel peiiods with d cumuldtive exposure of 8 392 peison-yedis dbdtdcept-tiedted RA pdtients weie dndlyzed. Obseived IRs foi infections requiting hospitdlizdtion duiing the double-blind peiiod weie pei 100-pdtient .
