Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis. | Palomino-Morales et al. Arthritis Research Therapy 2010 12 R71 http content 12 2 R71 RESEARCH ARTICLE Open Access A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis Rogelio Palomino-Morales41 Carlos Gonzalez-Juanatey42 Tomas R Vazquez-Rodriguez 3 Luis Rodriguez4 Jose A Miranda-Filloy3 Benjamin Fernandez-Gutierrez4 Javier Llorca5 Javier Martin41 and Miguel A Gonzalez-Gay 43 6 Abstract Introduction We determined the contribution of the methylene tetrahydrofolate reductase MTHFR 677 C T and 1298 A C gene polymorphisms to the susceptibility to rheumatoid arthritis RA . We also assessed whether these two MTHFR gene polymorphisms may be implicated in the development of cardiovascular CV events and subclinical atherosclerosis manifested by the presence of endothelial dysfunction in a series of Spanish patients with RA. Methods Six hundred and twelve patients fulfilling the 1987 American College of Rheumatology classification criteria for RA seen at the rheumatology outpatient clinics of Hospital Xeral-Calde Lugo and Hospital San Carlos Madrid were studied. Patients and controls n 865 were genotyped using predesigned TaqMan SNP genotyping assays. Results No significant differences in allele or genotype frequencies for the MTHFR gene polymorphisms between RA patients and controls were found. Also no association between the MTHFR 677 C T polymorphism and CV events or endothelial dysfunction was observed. However the MTHFR 1298 allele C frequency was increased in patients with CV events after 5 years versus odds ratio 95 confidence interval to P and 10 years versus odds ratio 95 confidence interval to P follow up. Moreover patients carrying the MTHFR 1298 AC and CC genotypes had a significantly decreased flow-mediated endothelium-dependent vasodilatation compared with those carrying the MTHFR 1298 AA genotype P . Conclusions .
