Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. | Beck et al. Arthritis Research Therapy 2010 12 R74 http content 12 2 R74 RESEARCH ARTICLE Open Access Chronic nonbacterial osteomyelitis in childhood prospective follow-up during the first year of anti-inflammatory treatment 1 1 2 23 -I- 4 5 Christine Beck Henner Morbach Meinrad Beer Martin Stenzel Dennis Tappe Stefan Gattenlohner Ulrich Hofmann6 Peter Raab7 Hermann J Girschick1 8 Abstract Introduction Chronic nonbacterial osteomyelitis CNO is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and treatment have rarely been reported. Methods Thirty-seven children diagnosed with CNO were treated with naproxen continuously for the first 6 months. If assessment at that time revealed progressive disease or no further improvement sulfasalazine and short-term corticosteroids were added. The aims of our short-term follow-up study were to describe treatment response in detail and to identify potential risk factors for an unfavorable outcome. Results Naproxen treatment was highly effective in general inducing a symptom-free status in 43 of our patients after 6 months. However four nonsteroidal anti-inflammatory drug NSAID partial-responders were additionally treated with sulfasalazine and short-term corticosteroids. The total number of clinical detectable lesions was significantly reduced. Mean disease activity estimated by the patient physician and the physical aspect of health-related quality of life including functional ability global assessment childhood health assessment questionnaire and childhood health assessment questionnaire and pain improved significantly. Forty-one percent of our patients showed radiological relapses but 67 of them were clinically silent. Conclusions Most children show a favorable clinical course in the first year of .
