Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Do we need new autoantibodies in lupus? | Scofield Arthritis Research Therapy 2010 12 120 http content 12 3 120 EDITORIAL L_ Do we need new autoantibodies in lupus R Hal Scofield See related research by Vázquez-Del Mercado etal. http content 12 1 R6 Abstract Systemic lupus erythematosus SLE is a clinically and serologically complex disease that demonstrates clinical epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are useful for diagnosis of the illness. Others are clinically important because of associations with a particular manifestation of SLE. Antibodies to RNA helicase A anti-RHA comprise a newly described class of SLE autoantibodies. These antibodies have so far been found only in SLE patients and differ substantially in prevalence and nature between Mexican and white American SLE patients. Study of anti-RHA may provide insights into the origin of population differences in SLE. Systemic lupus erythematosus SLE is a complex disease including serological differences between patients from different ethnicities 1 . Clinically the range of illness is great - patients may have life-threatening manifestations or the disease may not be much more than a nuisance. An SLE patient of ours once noted she was sitting next to someone else with SLE in the waiting area but that they seemed to have nothing in common but the diagnosis. The patient was understandably suspicious that two people could share the diagnosis but otherwise not have any shared feature. That one must meet only 4 of 11 criteria to be classified as SLE demonstrates that this is indeed the case 2 . Historically and perhaps still the major evidence that SLE is autoimmune is the presence of antibodies in the serum of SLE patients that bind self-structures. Here too the disease is extremely complex. Antinuclear antibody is a near-universal finding. Antibodies binding Correspondence hal-scofield@ Arthritis and Immunology Program Oklahoma .
