Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Immunomodulatory strategies prevent the development of autoimmune emphysema. | Hanaoka et al. Respiratory Research 2010 11 179 http content 11 1 179 RESPIRATORY RESEARCH RESEARCH Open Access Immunomodulatory strategies prevent the development of autoimmune emphysema Masayuki Hanaoka1 Mark R Nicolls2 Andrew P Fontenot1 Donatas Kraskauskas3 Douglas G Mack1 Adelheid Kratzer1 Jonas Salys1 Vita Kraskauskiene3 Nana Burns1 Norbert F Voelkel3 Laimute Taraseviciene-Stewart1 Abstract Background The presence of anti-endothelial cell antibodies and pathogenic T cells may reflect an autoimmune component in the pathogenesis of emphysema. Whether immune modulatory strategies can protect against the development of emphysema is not known. Methods Sprague Dawley rats were immunized with human umbilical vein endothelial cells HUVEC to induce autoimmune emphysema and treated with intrathymic HUVEC-injection and pristane. Measurements of alveolar airspace enlargement cytokine levels immuno histochemical western blot analysis and T cell repertoire of the lung tissue were performed. Results The immunomodulatory strategies protected lungs against cell death as demonstrated by reduced numbers of TUNEL and active caspase-3 positive cells and reduced levels of active caspase-3 when compared with lungs from HUVEC-immunized rats. Immunomodulatory strategies also suppressed anti-endothelial antibody production and preserved CNTF IL-1alpha and VEGF levels. The immune deviation effects of the intrathymic HUVEC-injection were associated with an expansion of CD4 CD25 Foxp3 regulatory T cells. Pristane treatment decreased the proportion of T cells expressing receptor beta-chain in the lung tissue. Conclusions Our data demonstrate that interventions classically employed to induce central T cell tolerance thymic inoculation of antigen or to activate innate immune responses pristane treatment can prevent the development of autoimmune emphysema. Background It is now increasingly recognized that chronic obstructive pulmonary disease COPD emphysema .
