Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study. | Polosa et al. Respiratory Research 2011 12 16 http content 12 1 16 RESPIRATORY RESEARCH RESEARCH Open Access Greater severity of new onset asthma in allergic subjects who smoke a 10-year longitudinal study 1 1 1 1 2 1 Riccardo Polosa Cristina Russo Pasquale Caponnetto Gaetano Bertino Maria Sarvà Tjana Antic Stefania Mancuso2 Wael K Al-Delaimy3 Abstract Background Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma. Methods Allergic rhinitis subjects with no asthma n 371 were followed-up for 10 years and routinely examined for asthma diagnosis. In those who developed asthma n 152 clinical severity and levels of asthma control were determined. Among these subjects 74 were current smokers 17 former smokers and 61 never smokers. Results When comparing current or past smokers to never smokers they had a higher risk of severe asthma in the univariate analysis which became non-significant in the multivariate analysis. On the other hand the categories of pack-years were significantly related to severe asthma in a dose response relationship in both the univariate and multivariate analysis compared to 0 pack years those who smoked 1-10 pack-years had an OR 95 CI of those who smoked 11-20 pack-years had an OR of and those who smoked more than 20 pack-years had an OR of to develop more severe asthma. Smokers with asthma were also more likely to have uncontrolled disease. A significant dose-response relationship was observed for pack-years and uncontrolled asthma. Compared to 0 pack years those who smoked 1-10 pack-years had an OR of and those who smoked more than 10 pack-years had an OR of to have uncontrolled asthma. Conclusions The current findings support the hypothesis that .