Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" b-thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up. | De Santis et al. Respiratory Research 2011 12 22 http content 12 1 22 RESPIRATORY RESEARCH RESEARCH Open Access p-thymosins and interstitial lung disease study of a scleroderma cohort with a one-year follow-up 1 2 112 2 Maria De Santis Rosanna Inzitari Silvia L Bosello Giusy Peluso Chiara Fanali Federica lavarone A A ĩ I 7 7r 1 R ỉ -A VI D I 1 I I 7I -A -A A l A r A r 3 I vr o R I r r A A 3 I Cl I 1 Z A4 c r -A r r r r D -A z t I I -A V I4 Gaetano Zizzo Mario Bocci Tiziana Cabras Irene Messana Leo Fuso Francesco Varone Gabriella Pagliari Massimo Castagnola2 5 Gianfranco Ferraccioli1 Abstract Background p-thymosins play roles in cytoskeleton rearrangement angiogenesis fibrosis and reparative process thus suggesting a possible involvement in the pathogenesis of systemic sclerosis. The aim of the study was to investigate the presence of thymosins p4 p4 sulfoxide and p10 in bronchoalveolar lavage fluid of scleroderma patients with interstitial lung disease and the relation of these factors with pulmonary functional and radiological parameters. Methods p-thymosins concentrations were determined by Reverse Phase-High Performance Liquid Chromatography-Electrospray-Mass Spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls. Results Thymosin p4 p4 sulfoxide and p10 were detectable in bronchoalveolar lavage fluid of patients and controls. Thymosin p4 levels were significantly higher in scleroderma patients than in controls. In addition analyzing the progression of scleroderma lung disease at one-year follow-up we have found that higher thymosin p4 levels seem to have a protective role against lung tissue damage. Thymosin p4 sulfoxide levels were higher in the smokers and in the scleroderma patients with alveolitis. Conclusions We describe for the first time p-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. Thymosin
