Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. | Wang et al. Respiratory Research 2011 12 26 http content 12 1 26 RESPIRATORY RESEARCH RESEARCH Open Access Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model Yun Wang Lei Jing Xiao-Min Zhao Ji-Ju Han Zuo-Li Xia Shu-Cun Qin Ya-Ping Wu Xue-Jun Sun 4 Abstract Background Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and or development of pulmonary hypertension. In this study we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. Methods In male Sprague-Dawley rats pulmonary hypertension was induced by subcutaneous administration of monocrotaline at a concentration of 6 mg 100 g body weight. Hydrogen-rich saline 5 ml kg or saline was administred intraperitoneally once daily for 2 or 3 weeks. Severity of pulmonary hypertension was assessed by hemodynamic index and histologic analysis. Malondialdehyde and 8-hydroxy-desoxyguanosine level and superoxide dismutase activity were measured in the lung tissue and serum. Levels of pro-inflammatory cytokines tumor necrosis factor-a interleukin-6 in serum were determined with enzyme-linked immunosorbent assay. Results Hydrogen-rich saline treatment improved hemodynamics and reversed right ventricular hypertrophy. It also decreased malondialdehyde and 8-hydroxy-desoxyguanosine levels and increased superoxide dismutase activity in the lung tissue and serum accompanied by a decrease in pro-inflammatory cytokines. Conclusions These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats which may be associated with its antioxidant and antiinflammatory effects. Background Pulmonary hypertension PH a syndrome that encompasses several diseases is .
