Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome. | Kondo et al. Respiratory Research 2011 12 32 http content 12 1 32 RESPIRATORY RESEARCH RESEARCH Open Access KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome 1 1 11 1 2 Tomohiro Kondo Noboru Hattori Nobuhisa Ishikawa Hiroshi Murai Yoshinori Haruta Nobuyuki Hirohashi Koichi Tanigawa2 Nobuoki Kohno1 Abstract Background KL-6 is a mucin-like glycoprotein expressed on the surface of alveolar type II cells. Elevated concentrations of KL-6 in serum and epithelial lining fluid ELF in patients with acute respiratory distress syndrome ARDS have been previously reported however kinetics and prognostic significance of KL-6 have not been extensively studied. This study was conducted to clarify these points in ARDS patients. Methods Thirty-two patients with ARDS who received mechanical ventilation under intubation were studied for 28 days. ELF and blood were obtained from each patient at multiple time points after the diagnosis of ARDS. ELF was collected using a bronchoscopic microsampling procedure and ELF and serum KL-6 concentrations were measured. Results KL-6 levels in ELF on days 0 to 3 after ARDS diagnosis were significantly higher in nonsurvivors than in survivors and thereafter there was no difference in concentrations between the two groups. Serum KL-6 levels did not show statistically significant differences between nonsurvivors and survivors at any time point. When the highest KL-6 levels in ELF and serum sample from each patient were examined KL-6 levels in both ELF and serum were significantly higher in nonsurvivors than in survivors. The optimal cut-off values were set at 3453 U mL for ELF and 530 U mL for serum by receiver operating characteristic ROC curve analyses. Patients with KL-6 concentrations in ELF higher than 3453 U mL or serum concentrations higher than 530 U mL had significantly lower survival rates up to 90 days after ARDS diagnosis. .