Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. | Miniati et al. Respiratory Research 2011 12 37 http content 12 1 37 RESPIRATORY RESEARCH RESEARCH Open Access Soluble receptor for advanced glycation end products in COPD relationship with emphysema and chronic cor pulmonale a case-control study 1 I- z- Massimo Miniati Simonetta Monti Giuseppina Basta Franca Cocci Edo Fornai and Matteo Bottai Abstract Background The receptor for advanced glycation end products RAGE is a multiligand signal transduction receptor that can initiate and perpetuate inflammation. Its soluble isoform sRAGE acts as a decoy receptor for RAGE ligands and is thought to afford protection against inflammation. With the present study we aimed at determining whether circulating sRAGE is correlated with emphysema and chronic cor pulmonale in chronic obstructive pulmonary disease COPD . Methods In 200 COPD patients and 201 age- and sex-matched controls we measured lung function by spirometry and sRAGE by ELISA method. We also measured the plasma levels of two RAGE ligands N-epsilon-carboxymethyl lysine and S100A12 by ELISA method. In the COPD patients we assessed the prevalence and severity of emphysema by computed tomography CT and the prevalence of chronic cor pulmonale by echocardiography. Multiple quantile regression was used to assess the effects of emphysema chronic cor pulmonale smoking history and comorbid conditions on the three quartiles of sRAGE. Results sRAGE was significantly lower p in COPD patients median 652 pg mL interquartile range 484 to 1076 pg mL than in controls median 869 pg mL interquartile range 601 to 1240 pg mL and was correlated with the severity of emphysema p the lower the level of sRAGE the greater the degree of emphysema on CT. The relationship remained statistically significant after adjusting for smoking history and comorbid conditions. In addition sRAGE was significantly lower in COPD patients with chronic cor pulmonale than in those without p . Such .
