Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review. | Wu et al. Respiratory Research 2011 12 45 http content 12 1 45 RESPIRATORY RESEARCH REVIEW Open Access Prospect of vasoactive intestinal peptide therapy for COPD PAH and asthma a review Dongmei Wu1 2 Dongwon Lee2 and Yong Kiel Sung3 Abstract There is mounting evidence that pulmonary arterial hypertension PAH asthma and chronic obstructive pulmonary disease COPD share important pathological features including inflammation smooth muscle contraction and remodeling. No existing drug provides the combined potential advantages of reducing vascular- and bronchial-constriction and anti-inflammation. Vasoactive intestinal peptide VIP is widely expressed throughout the cardiopulmonary system and exerts a variety of biological actions including potent vascular and airway dilatory actions potent anti-inflammatory actions improving blood circulation to the heart and lung and modulation of airway secretions. VIP has emerged as a promising drug candidate for the treatment of cardiopulmonary disorders such as PAH asthma and COPD. Clinical application of VIP has been limited in the past for a number of reasons including its short plasma half-life and difficulty in administration routes. The development of long-acting VIP analogues in combination with appropriate drug delivery systems may provide clinically useful agents for the treatment of PAH asthma and COPD. This article reviews the physiological significance of VIP in cardiopulmonary system and the therapeutic potential of VIP-based agents in the treatment of pulmonary diseases. 1. Introduction Vasoactive intestinal peptide VIP is a 28-amino-acid peptide which was first isolated from upper intestine and has been characterized as a vasodilatory peptide 1 . VIP has a very widespread distribution in the central and peripheral nervous systems 2 . It is one of the most abundant neuropeptides found in the cardiovascular system and airways 2-5 . This neuropeptide exerts a wide range of biological actions such
