Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Low bone mineral density in men with chronic obstructive pulmonary disease. | Duckers et al. Respiratory Research 2011 12 101 http content 12 1 101 RESPIRATORY RESEARCH RESEARCH Open Access Low bone mineral density in men with chronic obstructive pulmonary disease I s m ft A r 1 Ir r 1D t A r A I Ct s r 2 A ỉ I I I KỲ l h E r t r ft V3 h A I r A f I l A 4 A r I E Drt I rt 1 5 l s L . .r-J James M DUGKers Bronwen AJ Evans William D Fraser Micnaei D Stone Charlotte E Bolton ano Dennis J Shale1 Abstract Background Osteoporosis is common in patients with COPD but the likely multi-factorial causes contributing to this condition . sex age smoking therapy mask the potential contribution from elements related to COPD. In order to study osteoporosis and bone mineral density BMD related to COPD we studied a well-defined group of patients and controls. Methods BMD forced expiratory volume in one second FEV1 circulating bone biomarkers and biochemistry were determined in 30 clinically stable male ex-smokers with confirmed COPD and 15 age matched ex-smoker male controls. None of the patients were on inhaled corticosteroids or received more than one short course of steroids. Results Mean SD FEV1 predicted of patients was 64 6 the majority having Global Initiative for Chronic Obstructive Lung Disease GOLD II airflow obstruction. There were 5 30 patients and 1 15 controls who were osteoporotic while a further 17 patients and 5 controls were osteopenic. The BMD at the hip was lower in patients than controls but not at the lumbar spine. Mean values of procollagen type 1 amino-terminal propeptide and osteocalcin both markers of bone formation and Type 1 collagen b C-telopeptide a marker of bone resorption were similar between patients and controls. However all bone biomarkers were inversely related to hip BMD in patients r r r p but did not relate to lumbar spine BMD. 25-OH Vitamin D was lower in patients. Conclusions Men with COPD had a greater prevalence of osteoporosis and osteopenia than age matched
