Báo cáo y học: " Treatment of allergic asthma: Modulation of Th2 cells and their responses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Treatment of allergic asthma: Modulation of Th2 cells and their responses. | Bosnjak et al. Respiratory Research 2011 12 114 http content 12 1 114 RESPIRATORY RESEARCH REVIEW Open Access Treatment of allergic asthma Modulation of Th2 cells and their responses Berislav Bosnjak1 Barbara Stelzmueller1 Klaus J Erb2 and Michelle M Epstein1 Abstract Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent episodes of wheezy laboured breathing with an underlying Th2 cell-mediated inflammatory response in the airways. It is currently treated and more or less controlled depending on severity with bronchodilators . long-acting beta agonists and long-acting muscarinic antagonists or anti-inflammatory drugs such as corticosteroids inhaled or oral leukotriene modifiers theophyline and anti-IgE therapy. Unfortunately none of these treatments are curative and some asthmatic patients do not respond to intense anti-inflammatory therapies. Additionally the use of long-term oral steroids has many undesired side effects. For this reason novel and more effective drugs are needed. In this review we focus on the CD4 Th2 cells and their products as targets for the development of new drugs to add to the current armamentarium as adjuncts or as potential stand-alone treatments for allergic asthma. We argue that in early disease the reduction or elimination of allergen-specific Th2 cells will reduce the consequences of repeated allergic inflammatory responses such as lung remodelling without causing generalised immunosuppression. Introduction Asthma is a serious chronic inflammatory lung disease characterised by recurrent episodes of wheezy laboured breathing with prolonged expiration accompanied by dry coughing and viscous mucus. These symptoms result from bronchoconstriction bronchial mucosal thickening by oedema eosinophilic infiltration bronchial wall remodelling and excessive mucus production with plugging of the conducting airways in the lungs. These airway changes lead to increased bronchial .

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