Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. | RESPIRATORY RESEARCH Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension Dorfmuller et al. Dorfmuller et al. Respiratory Research 2011 12 119 http content 12 1 119 9 September 2011 BioMed Central Dorfmuller et al. Respiratory Research 2011 12 119 http content 12 1 119 RESEARCH RESPIRATORY RESEARCH Open Access Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension D S-. S-. u- r l v-fV V I I I IS-. u- 1 2 3 4h ỉ u- I r I I I r H I I m s I r 1 3 ỉ r I I s s l z I I I 13 I r I I FA I I I 0 s r r S-. I I 2 I I r- I r- D í rrvr r I3 4 Peter uorrmuller Ividrie-Cdmille Chdumdis Mdrid Gidnndkouli Ingria uurdnd-Gdsselin Nicolds Rdymond 5 Elie Fddel Oldf Mercier Frédéric Chdrlotte Ddvid Montdni Gérdld Simonnedu Mdrc Humbert dnd Frédéric Perros1 3 Abstract Background Involvement of infldmmdtion in pulmondry hypertension PH hds previously been demonstrated 3nd recently immune-moduldting dendritic cells DCs infiltrating drteridl lesions in pdtients suffering from idiopdthic pulmondry drteridl hypertension IPAH dnd in experimentdl monocrotdline-induced PH hdve been reported. Occurrence of perivdsculdr infldmmdtory cells could be linked to locdl incredse of oxiddtive stress OS ds it hds been shown for systemic dtherosclerosis. The impdct of OS on vdsculdr remodeling in PH is still to be determined. We hypothesized thdt dugmented blood-flow could incredse OS dnd might thereby contribute to DC infldmmdtory cell-recruitment dnd smooth-muscle-cell-proliferation. Methods We dpplied d monocrotdline-induced PH-model dnd combined it with permdnent flow-chdllenge. Thirty Sprdgue-Ddwley rats were dssigned to following groups control monocrotdline-exposure MCT monocrotdline-exposure pneumonectomy MCT PE . Results Hemodyndmic exploration demonstrated
