Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial. | Kesten et al. Respiratory Research 2011 12 129 http content 12 1 129 RESPIRATORY RESEARCH RESEARCH Open Access Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial Steven Kesten1 Bartolomé Celli2 Marc Decramer3 Dacheng Liu1 and Donald Tashkin4 Abstract Background The rate of decline in forced expiratory volume in 1 second FEV1 is representative of the natural history of COPD. Sparse information exists regarding the associations between the magnitude of annualised loss of FEV1 with other endpoints. Methods Retrospective analysis of UPLIFT trial four-year randomized double-blind placebo-controlled trial of tiotropium 18 pg daily in chronic obstructive pulmonary disease COPD n 5993 . Decline of FEV1 was analysed with random co-efficient regression. Patients were categorised according to quartiles based on the rate of decline RoD in post-bronchodilator FEV1. The St George s Respiratory Questionnaire SGRQ total score exacerbations and mortality were assessed within each quartile. Results Mean standard error SE post-bronchodilator FEV1 increased in the first quartile Q1 by 37 1 mL year. The other quartiles showed annualised declines in FEV1 mL year as follows Q2 24 1 Q3 59 1 and Q4 125 2 . Age gender respiratory medication use at baseline and SGRQ did not distinguish groups. The patient subgroup with the largest RoD had less severe lung disease at baseline and contained a higher proportion of current smokers. The percentage of patients with 1 exacerbation showed a minimal difference from the lowest to the largest RoD but exacerbation rates increased with increasing RoD. The highest proportion of patients with 1 hospitalised exacerbation was in Q4 Q1 tiotropium 26 control Q4 tiotropium and control . Time to first exacerbation and hospitalised exacerbation was shorter with increasing RoD. Rate of decline in SGRQ increased in direct proportion to each quartile. The group with the .
