Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Relative receptor affinity comparisons among inhaled/intranasal corticosteroids: perspectives on clinical relevance. | Respiratory Research BioMed Central Letter to the Editor Relative receptor affinity comparisons among inhaled intranasal corticosteroids perspectives on clinical relevance Gunther Hochhaus Open Access Address University of Florida College of Pharmacy Gainesville Florida USA Email Gunther Hochhaus - hochhaus@ Published 24 November 2008 Received 16 May 2008 Accepted 24 November 2008 Respiratory Research 2008 9 75 doi l465-992l -9-75 p This article is available from http content 9 l 75 2008 Hochhaus licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pharmacokinetic properties dosing regimen and potency at the site of action are among the factors that influence activity of a corticosteroid. The potency of a corticosteroid at the site of action is determined significantly by its affinity to the glucocorticoid receptor. Recent literature on topical corticosteroids reveals an increasing emphasis on comparative relative receptor affinity values as a key method of differentiating among various corticosteroid compounds particularly with regard to clinical efficacy. Methods A response was formulated to Valotis A Hogger P Human receptor kinetics and lung tissue retention of the enhanced-affinity glucocorticoid fluticasone furoate. Respir Res 2007 8 54. Results Relative receptor binding affinities while often showing significant variability across different laboratories are a valid parameter when a comparison of the pharmacological activity of various glucocorticoids at the site of action is desired. Unfortunately within this context scientific literature including the article from Valotis and Hogger confuse differences in potency concentration or dose necessary to achieve a .
