Báo cáo y học: "Attenuation of acute lung inflammation induced by cigarette smoke in CXCR3 knockout mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Attenuation of acute lung inflammation induced by cigarette smoke in CXCR3 knockout mice. | Respiratory Research BioMed Central Research Attenuation of acute lung inflammation induced by cigarette smoke in CXCR3 knockout mice Li Nie11 2 Ruolan Xiangt3 Weixun Zhout4 Bao Lu5 Deyun Cheng2 and Jinming Gao 1 Address Department of Respiratory Disease Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 PR China 2Department of Respiratory Disease West China Hospital Sichuan University Chengdu 610041 Sichuan Province PR China 3Department of Pathophysiology Peking University Health Sciences Center Beijing 100088 PR China 4Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 PR China and 5Ina Sue Perlmutter Laboratory Division of Pulmonary Children s Hospital Harvard Medical School Boston MA 02115 USA Email Li Nie - bywaters@ Ruolan Xiang - xiangruolan@ Weixun Zhou - zweixun@ Bao Lu - Deyun Cheng - chengdeyun@ Jinming Gao - gjinming@ Corresponding author tEqual contributors Open Access Published 16 December 2008 Respiratory Research 2008 9 82 doi 1465-9921 -9-82 Received 22 June 2008 Accepted 16 December 2008 This article is available from http content 9 1 82 2008 Nie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CD8 T cells may participate in cigarette smoke CS induced-lung inflammation in mice. CXCL10 IP-10 IFNy-inducible protein 10 and CXCL9 Mig monokine induced by IFN-y are up-regulated in CS-induced lung injury and may attract T-cell recruitment to the lung. These chemokines together with CXCL11 ITAC IFN-inducible T-cell alpha chemoattractant

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