Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD. | Respiratory Research BioMed Central Open Access Smad gene expression in pulmonary fibroblasts indications for defective ECM repair in COPD Andre Zandvoort1 2 Dirkje S Postma2 Marnix R Jonker1 2 Jacobien A Noordhoek2 Johannes TWM Vos1 and Wim Timens 1 Address Department of Pathology University Medical Center Groningen University of Groningen Hanzeplein 1 NL-9713 GZ Groningen The Netherlands and 2Department of Pulmonology University Medical Center Groningen University of Groningen Hanzeplein 1 NL-9713 GZ Groningen The Netherlands Email Andre Zandvoort - Dirkje S Postma - Marnix R Jonker - Jacobien A Noordhoek - Johannes TWM Vos - Wim Timens - Corresponding author Published 16 December 2008 Received 10 April 2008 Respiratory Research 2008 9 83 doi 1465-9921 -9-83 Accepted 16 December 2008 This article is available from http content 9 1 83 2008 Zandvoort et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chronic Obstructive Pulmonary Disease COPD is characterized by defective extracellular matrix ECM turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFP induced Smad pathway provides intracellular signals to regulate ECM production. We address the following hypothesis fibroblasts have abnormal expression of genes in the Smad pathway in COPD resulting in abnormal proteoglycan modulation the ground substance of ECM. Methods We compared gene expression of the Smad pathway at different time points after stimulation with TGFp TNF or cigarette smoke extract CSE in pulmonary .
