Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. | Respiratory Research BioMed Central Open Access Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice Laurent Savale 1 2 Ly Tu1 Dominique Rideau1 Mohamed Izziki1 Bernard Maitre1 3 Serge Adnot1 2 and Saadia Eddahibi1 Address 1INSERM U841 Université Paris XII F94010 Créteil France 2AP-HP Hôpital Henri Mondor Service de Physiologie Explorations Fonctionnelles F94010 Créteil France and 3AP-HP Hôpital Henri Mondor Unité de Pneumologie F94010 Créteil France Email Laurent Savale - Ly Tu - Dominique Rideau - Mohamed Izziki - Bernard Maitre - Serge Adnot - Saadia Eddahibi - Corresponding author Published 27 January 2009 Respiratory Research 2009 10 6 doi l465-992l-l0-6 Received 18 September 2008 Accepted 27 January 2009 This article is available from http content 10 1 6 2009 Savale et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension PH . Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 IL-6 . Methods To determine whether endogenous IL-6 contributes to mediate hypoxic PH and lung inflammation we studied IL-6-deficient IL-6- - and wild-type IL-6 mice exposed to hypoxia for 2 weeks. Results Right ventricular systolic pressure right ventricle hypertrophy and the number and media thickness of muscular pulmonary vessels were decreased in IL-6- - mice compared to wildtype controls after 2 weeks hypoxia although the .
