Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure. | Respiratory Research BioMed Central Research Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure Michael J Linke1 2 Alan D Ashbaugh2 Jeffery A Demland2 and Peter D Walzer 1 2 Open Access Address Research Service Veterans Affairs Medical Center Cincinnati OH USA and 2Division of Infectious Diseases Department of Internal Medicine College of Medicine University of Cincinnati Cincinnati OH USA Email Michael J Linke - Alan D Ashbaugh - ashbauad@ Jeffery A Demland - demlanja@ Peter D Walzer - Corresponding author Published 19 February 2009 Received I July 2008 Respiratory Research 2009 10 10 doi 1465-9921-10-10 Accepted 19 February 2009 This article is available from http content 10 1 10 2009 Linke et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pneumocystis spp. are opportunistic pathogens that cause pneumonia in immunocompromised humans and animals. Pneumocystis colonization has also been detected in immunocompetent hosts and may exacerbate other pulmonary diseases. Surfactant protein A SPA is an innate host defense molecule and plays a role in the host response to Pneumocystis. Methods To analyze the role of SP-A in protecting the immunocompetent host from Pneumocystis colonization the susceptibility of immunocompetent mice deficient in SP-A KO and wild-type WT mice to P. murina colonization was analyzed by reverse-transcriptase quantitative PCR qPCR and serum antibodies were measured by enzyme-linked immunosorbent assay ELISA . Results Detection of P. murina specific serum antibodies in immunocompetent WT and KO mice indicated that the
