Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "The effect of tiotropium therapy on markers of elastin degradation in COPD. | Respiratory Research BioMed Central Research The effect of tiotropium therapy on markers of elastin degradation in COPD Shuren Ma Yong Y Lin Lori Tartell and Gerard M Turino Address James P. Mara Center for Lung Disease St. Luke s-Roosevelt Hospital Center 1000 Tenth Avenue New York NY 10019 USA Email Shuren Ma - sm2202@ Yong Y Lin - yylin@ Lori Tartell - ltartell@ Gerard MTurino - gmt1@ Corresponding author Open Access Published 25 February 2009 Received 19 September 2008 Respiratory Research 2009 10 12 doi 1465-9921-10-12 Accepted 25 February 2009 This article is available from http content 10 1 12 2009 Ma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Desmosine and Isodesmosine D I are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity. This study was undertaken to determine whether continuous therapy with the long-acting bronchodilator Tiotropium bromide TTP could result in reductions in D I as measured by mass spectrometry in plasma urine and sputum. Methods Twelve not currently smoking patients with chronic obstructive pulmonary disease COPD never on TTP were selected for study. Levels of D I along with measurements of FVC FEV1 and FEV1 FVC. were determined before starting TTP daily and then one and two months after. Results D I decreased in plasma 10 of 12 patients in sputum all 12 of12 and in the percentage of free D I in urine 10 of 12 . Most patients showed slight increases in FVC
