Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction. | Respiratory Research BioMed Central Research Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung implications for allergen-induced bronchoconstriction Anna-Karin Larsson 1 2 Magnus Back3 Jon O Lundberg4 and Sven- Erik Dahlén2 Open Access Address 1Unit of Lung Biology Division of Vascular and Respiratory Research Department of Experimental Medical Science Lund University Lund Sweden 2Unit of Experimental Asthma and Allergy Research Division of Physiology The National Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden 3Department of Cardiology and Center for Molecular Medicine Karolinska Institutet Stockholm Sweden and 4Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden Email Anna-Karin Larsson - Magnus Back - Jon O Lundberg - Sven-Erik Dahlén - Corresponding author Published 4 June 2009 Received 14 November 2008 Respiratory Research 2009 10 46 doi l465-992l-l0-46 Accepted 4 June 2009 This article is available from http content l0 l 46 2009 Larsson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The aim of this study was to examine potential therapeutic effect of the two NO donors NCX 2057 3- 4-hydroxy-3-methoxyphenyl -2-propenoic acid 4- nitrooxy butyl ester and SNP sodium nitroprusside on the early allergic airway response in the peripheral lung. Methods The experiments were performed in guinea pig lung parenchyma GPLP derived from ovalbumin OVA sensitized guinea pigs. The effects of NCX 2057 and SNP were evaluated by contractile responses and mediator release during OVA challenge. The .
