Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial. | Respiratory Research BioMed Central Research Concomitant therapy with Cineole Eucalyptole reduces exacerbations in COPD A placebo-controlled double-blind trial Heinrich Worth 1 Christian Schacher1 and Uwe Dethlefsen2 Open Access Address 1Hospital Furth University Erlangen-Nurnberg Jakob-Henle-Str. 1 D-90766 Furth Germany and 2MKL Institute of Clinical Research Pauwelsstr. 19 D-52074 Aachen Germany Email Heinrich Worth - med1@ Christian Schacher - med1@ Uwe Dethlefsen - mklklifo@ Corresponding author Published 22 July 2009 Received 8 January 2009 Respiratory Research 2009 10 69 doi 1465-9921-10-69 Accepted 22 July 2009 This article is available from http content 10 1 69 2009 Worth et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The clinical effects of mucolytics in patients with chronic obstructive pulmonary disease COPD are discussed controversially. Cineole is the main constituent of eucalyptus oil and mainly used in inflammatory airway diseases as a mucolytic agent. We hypothesised that its known mucolytic bronchodilating and anti-inflammatory effects as concomitant therapy would reduce the exacerbation rate and show benefits on pulmonary function tests as well as quality of life in patients with COPD. Methods In this double-blind placebo-controlled multi-center-study we randomly assigned 242 patients with stable COPD to receive 200 mg of cineole or placebo 3 times daily as concomitant therapy for 6 months during winter-time. The frequency duration and severity of exacerbations were combined as primary outcome measures for testing as .
