Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies. | Respiratory Research BioMed Central Research MMP TIMP expression profiles in distinct lung disease models implications for possible future therapies Sissie Wong Maria G Belvisi and Mark A Birrell Open Access Address Respiratory Pharmacology Group Airways Disease Section Imperial College London Faculty of Medicine National Heart and Lung Institute 1st Floor Room 102 Sir Alexander Fleming Building South Kensington Campus Exhibition Road London SW7 2AZ Email Sissie Wong - Maria G Belvisi - Mark A Birrell - Corresponding author Published 3 August 2009 Received 28 January 2009 Respiratory Research 2009 10 72 doi 1465-9921-10-72 Accepted 3 August 2009 This article is available from http content 10 1 72 2009 Wong et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background There is currently a vast amount of evidence in the literature suggesting that matrix metalloproteinases MMPs and tissue inhibitors of metalloproteinases TIMPs are involved in the pathogenesis of inflammatory airways diseases such as asthma and COPD. Despite this the majority of reports only focus on single MMPs often only in one model system. This study aimed to investigate the profile of an extensive range of MMP TIMP levels in three different pre-clinical models of airways disease. These models each have a different and very distinct inflammatory profile each exhibiting inflammatory characteristics that are similar to that observed in asthma or COPD. Since these models have their own characteristic pathophysiological phenotype one would speculate that
