Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. | Respiratory Research BioMed Central Open Access Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAPI in the general population Mateusz Siedlinski1 Dirkje S Postma2 Jolanda MA Boer3 Gerrit van der Steege4 Jan P Schouten1 Henriette A Smit3 and H Marike Boezen 1 Address Department of Epidemiology University Medical Center Groningen University of Groningen Groningen The Netherlands 2Department of Pulmonology University Medical Center Groningen University of Groningen Groningen The Netherlands 3National Institute for Public Health and the Environment Bilthoven The Netherlands and 4Department of Medical Genetics University Medical Center Groningen University of Groningen Groningen The Netherlands Email Mateusz Siedlinski - Dirkje S Postma - Jolanda MA Boer - Gerrit van der Steege - Jan P Schouten - Henriette A Smit - H Marike Boezen - Corresponding author Published II August 2009 Received 31 March 2009 Respiratory Research 2009 10 73 doi 1465-9921-10-73 Accepted 1 1 August 2009 This article is available from http content 10 1 73 2009 Siedlinski et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 NFE2L2 or NRF2 and its cytosolic repressor Kelch-like ECH-associated protein-1 KEAP1 regulate transcription of enzymes involved in cellular detoxification processes and Nfe2 2-deficient mice develop tobacco-induced emphysema.
