Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Long-term gas exchange characteristics as markers of deterioration in patients with cystic fibrosis. | Respiratory Research BioMed Central Open Access Long-term gas exchange characteristics as markers of deterioration in patients with cystic fibrosis Richard Kraemer 1 Philipp Latzin1 2 Isabelle Pramana1 2 Pietro Ballinari4 Sabina Gallati1 3 and Urs Frey1 2 Address Department of Paediatrics University of Berne Inselspital CH-3010 Berne Switzerland 2Division of Paediatric Respiratory Medicine Department of Paediatrics University of Berne Inselspital CH-3010 Berne Switzerland 3Division of Human Genetics Department of Clinical Research University of Berne CH-3010 Berne. Switzerland and institute of Psychology University of Berne Muesmattstr. 45 CH-3000 Bern Switzerland Email Richard Kraemer - Philipp Latzin - Isabelle Pramana - Pietro Ballinari - Sabina Gallati - Urs Frey - Corresponding author Published 12 November 2009 Received 4 August 2009 Respiratory Research 2009 10 106 doi l465-992l-l0-l06 Accepted 12 November 2009 This article is available from http content l0 l 106 2009 Kraemer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background and Aim In patients with cystic fibrosis CF the architecture of the developing lungs and the ventilation of lung units are progressively affected influencing intrapulmonary gas mixing and gas exchange. We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence of different CFTR genotype upon this process. Methods Serial annual measurements of PaO2 and PaCO2 assessed in relation to lung function providing functional residual capacity
