Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Bronchoalveolar lavage fluid from preterm infants with chorioamnionitis inhibits alveolar epithelial repair. | Respiratory Research BioMed Central Research Bronchoalveolar lavage fluid from preterm infants with chorioamnionitis inhibits alveolar epithelial repair Jasper V Been 1 Luc JI Zimmermann1 Anne Debeer2 Nico Kloosterboer1 and J Freekvan Iwaarden1 Address Department of Paediatrics School for Oncology and Developmental Biology GROW Maastricht University Medical Centre PO Box 5800 6202 AZ Maastricht the Netherlands and 2Department of Neonatology University Hospital Gasthuisberg Herestraat 49 3000 Leuven Belgium Email Jasper V Been - Luc JI Zimmermann - Anne Debeer - Nico Kloosterboer - J Freek van Iwaarden - Corresponding author Open Access Published 23 November 2009 Received 22 June 2009 Accepted 23 November 2009 Respiratory Research 2009 10 116 doi 1465-9921-10-116 This article is available from http content 10 1 1 16 2009 Been et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Preterm infants are highly susceptible to lung injury. While both chorioamnionitis and antenatal steroids induce lung maturation chorioamnionitis is also associated with adverse lung development. We investigated the ability of bronchoalveolar lavage fluid BALF from ventilated preterm infants to restore alveolar epithelial integrity after injury in vitro depending on whether or not they were exposed to chorioamnionitis or antenatal steroids. For this purpose a translational model for alveolar epithelial repair was developed and characterised. Methods BALF was added to mechanically wounded monolayers of A549 cells. Wound closure was quantified over time and compared .
