Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. | Respiratory Research BioMed Central Open Access Secondhand smoke inhibits both Cl- and K conductances in normal human bronchial epithelial cells Amy N Savitski1 Clementina Mesaros3 Ian A Blair3 Noam A Cohen4 and James L Kreindler 1 2 Address division of Pulmonary Medicine The Children s Hospital of Philadelphia Philadelphia PA USA 2Department of Pediatrics University of Pennsylvania School of Medicine Philadelphia PA USA 3Centers for Cancer Pharmacology and Excellence in Environmental Toxicology Department of Pharmacology University of Pennsylvania School of Medicine Philadelphia PA USA and 4Division of Rhinology Department of Otorhinolaryngology University of Pennsylvania School of Medicine Philadelphia PA USA Email Amy N Savitski - Clementina Mesaros - mesaros@ Ian A Blair - ianblair@ Noam A Cohen - James L Kreindler - kreindler@ Corresponding author Published 27 November 2009 Received 5 August 2009 Respiratory Research 2009 10 120 doi 1465-9921-10-120 Accepted 27 November 2009 This article is available from http content 10 1 120 2009 Savitski et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Secondhand smoke SHS exposure is an independent risk factor for asthma rhinosinusitis and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subsequent mucus retention contributes to the pathophysiology of each of these diseases suggesting that altered epithelial salt and water transport may play an etiological role. To test the hypothesis that SHS would alter epithelial ion transport we designed a system for in vitro exposure of mature .
