Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation. | Maes et al. Respiratory Research 2010 11 7 http content 11 1 7 RESPIRATORY RESEARCH REVIEW Open Access Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation Tania Maes1 Sharen Provoost1 Ellen A Lanckacker1 Didier D Cataldo2 3 Jeroen AJ Vanoirbeek4 Benoit Nemery4 Kurt G Tournoy1 Guy F Joos1 Abstract Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke MS and environmental tobacco smoke ETS as well as exposure to diesel exhaust particles DEP could promote allergic sensitization or aggravate symptoms of asthma suggesting a role for these inhaled pollutants in the pathogenesis of asthma. Mouse models are a valuable tool to study the potential effects of these pollutants in the pathogenesis of asthma with the opportunity to investigate their impact during processes leading to sensitization acute inflammation and chronic disease. Mice allow us to perform mechanistic studies and to evaluate the importance of specific cell types in asthma pathogenesis. In this review the major clinical effects of tobacco smoke and diesel exhaust exposure regarding to asthma development and progression are described. Clinical data are compared with findings from murine models of asthma and inhalable pollutant exposure. Moreover the potential mechanisms by which both pollutants could aggravate asthma are discussed. Introduction Asthma is a chronic inflammatory disorder of the airways. The clinical hallmark of asthma is bronchial hyperresponsiveness with recurrent episodes of wheezing breathlessness chest tightness and cough. These episodes are associated with variable airflow obstruction that is at least partially reversible 1 . Asthma is a considerable public health concern with an increasing prevalence and an estimate of 300 million asthmatics worldwide. Although the cause of asthma is unknown there are several risk factors that .
