Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mesenchymal stem cells in autoimmune diseases: hype or hope? | Scherer et al. Arthritis Research Therapy 2010 12 126 http content 12 3 126 EDITORIAL L_ Mesenchymal stem cells in autoimmune diseases hype or hope Hans U Scherer1 2 Melissa van Pel3 and René EM Toes 1 See related research by Schurgers etal. http content 12 1 R31 Abstract Intervention with mesenchymal stem cells MSCs represents a promising therapeutic tool in treatmentrefractory autoimmune diseases. A new report by Schurgers and colleagues in a previous issue of Arthritis Research Therapy sheds novel mechanistic insight into the pathways employed by MSCs to suppress T-cell proliferation in vitro but at the same time indicates that MSCs do not influence T-cell reactivity and the disease course in an in vivo arthritis model. Such discrepancies between the in vitro and in vivo effects of potent cellular immune modulators should spark further research and should be interpreted as a sign of caution for the in vitro design of MSC-derived interventions in the setting of human autoimmune diseases. Immunomodulation by mesenchymal stem cells in vitro and in vivo Mesenchymal stem cells MSCs are multipotent progenitor cells that can be cultured from various adult and fetal tissues and that are capable of differentiating into multiple mesenchymal lineages including bone cartilage tendon marrow stroma and adipose tissue 1 . Because of their unique regenerative potential MSCs are considered a promising therapeutic modality for tissue regeneration and repair. Moreover MSCs are thought to be critically involved in the formation of survival niches for memory T cells and B cells in the bone marrow thereby regulating the size stability and plasticity of immunological memory. Awareness has additionally been raised by the finding that MSCs display immunomodulatory properties in vitro as evidenced by their ability to inhibit T-cell proliferation. This inhibition affects the proliferation of T cells Correspondence .
