Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study. | Bang et al. Arthritis Research Therapy 2010 12 R115 http content 12 3 R115 RESEARCH ARTICLE Open Access Pepjtidyl arginine deiminase type IV PADI4 haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis a case control study So-Young Bang 1 Tae-Un Han2 Chan-Bum Choi1 Yoon-Kyoung Sung1 Sang-Cheol Bae 1 and Changwon Kang 2 Abstract Introduction Anti-cyclic citrullinated peptide autoantibodies anti-CCP are the most specific serologic marker for rheumatoid arthritis RA . Genetic polymorphisms in a citrullinating or deiminating enzyme peptidyl arginine deiminase type IV PADI4 have been reproducibly associated with RA susceptibility in several populations. We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA whether they influence disease severity erosive joint status and whether they interact with two major risk factors for RA Human Leukocyte Antigen-DRB1 HLA-DRB1 shared epitope SE alleles and smoking depending on anti-CCP and erosive joint status. Methods All 2 317 unrelated Korean subjects including 1 313 patients with RA and 1 004 unaffected controls were genotyped for three nonsynonymous padi4_89 padi4_90 and padi4_92 and one synonymous padi4_104 singlenucleotide polymorphisms SNPs in PADI4 and for HLA-DRB1 by direct DNA sequence analysis. Odds ratios OR were calculated by multivariate logistic regression. Interaction was evaluated by attributable proportions AP with 95 confidence intervals CI . Results A functional haplotype of the three fully correlated nonsynonymous SNPs in PADI4 was significantly associated with susceptibility to not only anti-CCP-positive adjusted OR 95 CI to but also -negative RA adjusted OR 95 CI to . A strong association with both non-erosive adjusted OR 95 CI to and erosive RA adjusted OR 95 CI to was observed for PADI4 .
