Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. | Helmark et al. Arthritis Research Therapy 2010 12 R126 http content 12 4 R126 RESEARCH ARTICLE Open Access Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis a randomized controlled trial Ida C Helmark 1 Ulla R Mikkelsen1 Jens B0rglum2 Anders Rothe2 Marie CH Petersen1 Ove Andersen3 Henning Langberg1 and Michael Kjaer1 Abstract Introduction The microdialysis method was applied to the human knee joint with osteoarthritis OA in order to reveal changes in biochemical markers of cartilage and inflammation intraarticularly and in the synovium in response to a single bout of mechanical joint loading. Methods Thirty-one female subjects with OA of the knee were randomized to non-exercise NEx or exercise Ex groups. Following acute resistance exercise 25 sets of 10 repetitions at 60 of 1 Repetition Maximum or none NEx peripheral nerve blocks just below the inguinal ligament were applied and two microdialysis catheters were positioned in two different compartments intraarticularly and peri-synovially. The microdialysis catheters were perfused at a slow rate 2 p minute with a solution of Ringer-acetate and radioactively labelled glucose allowing for determination of relative recovery RR and calculation of interstitial concentrations of inflammatory and cartilage biomarkers over a three-hour period. Results A significant increase of Interleukin IL -10 was discovered in both positions of the knee in the Ex group over the three hours post exercise whereas IL-10 remained stationary over time in the NEx group. IL-6 and IL-8 displayed significant increases over time regardless of group and position of the catheter. Cartilage oligomeric matrix protein COMP decreased intraarticularly in the post exercise period in the Ex group compared to the NEx group. Conclusions Exercise caused an increase in both intraarticular and peri-synovial concentrations of IL-10 in a group of human females with knee .
