Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Osteoarthritis and a high-fat diet: the full ‘OA syndrome’ in a small animal model. | van der Kraan Arthritis Research Therapy 2010 12 130 http content 12 4 130 EDITORIAL L_ Osteoarthritis and a high-fat diet the full OA syndrome in a small animal model Peter M van der Kraan See related research by Griffin etal. http content 12 4 R130 Abstract Obesity is one of the main risk factors for osteoarthritis OA and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and that this is related to alterations in locomotor function. Furthermore a high-fat diet leads to pain sensitization and depression anxiety-like behavior unrelated to structural OA changes in the knee. Their findings demonstrate that the majority of features of the human OA syndrome can be reproduced in a small animal model. Osteoarthritis OA is the most common joint disease and affects a large proportion of the population mainly the elderly. Besides aging obesity is one of the most important risk factors for OA. Due to the global obesity epidemic it is becoming more and more important to unravel the role of obesity in both structural and symptomatic OA. The article of Griffin and colleagues in Arthritis Research and Therapy is one of first studies to integrate in a high-fat-induced small animal model of OA the subsequent obesity and biochemical neurobehavioral musculoskeletal inflammatory and structural knee joint changes 1 . Many aspects of the spectrum of structural and symptomatic findings in human OA appear to be reproduced in this murine obesity-associated model. Griffin and colleagues fed C57Bl6 6j mice a low- or high-fat diet until 54 weeks of age. Remarkably although an inbred strain was used a dichotomy within the Correspondence Experimental Rheumatology and Advanced Therapeutics Radboud University Nijmegen .
