Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis. | Anderson et al. Arthritis Research Therapy 2010 12 R147 http content 12 4 R147 RESEARCH ARTICLE Open Access Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis 2 2 2 31 Rebecca Anderson 11 Angels Franch 1 Margarida Castell Francisco J Perez-Cano Rolf Brauer Dirk Pohlers K lio 7 cItỉ a ÍO2 i H23 A Iov2nH rr ic n Ciclzr ic4 IZ fci Itỉ4 Tti m 3 l 7 xrxfxi ilr tc4 I icHHtỉi IC5 Mieczyslaw Gajda 1 Alexandros P Siskos 1 Iiieodoia Katsila 1 Constantin lamvakopoulos 1 Una Rauchhaus 1 Steffen Panzner51 Raimund W Kinne1 Abstract Introduction The objective of this study was to evaluate the efficacy of intravenous . injection of liposomally encapsulated dexamethasone phosphate DxM-P in comparison to free DxM-P in rats with established adjuvant arthritis AA . This study focused on polyethylene glycol PEG -free liposomes1 to minimize known allergic reactions caused by neutral PEG-modified PEG-ylated liposomes. Methods Efficacy was assessed clinically and histologically using standard scores. Non-specific and specific immune parameters were monitored. Activation of peritoneal macrophages was analyzed via cytokine profiling. Pharmacokinetics biodistribution of DxM in plasma1 synovial membrane1 spleen and liver were assessed via mass spectrometry. Results Liposomal DxM-P 3 X 1 mg kg body weight administered intravenously . on Days 141 15 and 16 of AA suppressed established AA1 including histological signs1 erythrocyte sedimentation ratez white blood cell count circulating anti-mycobacterial IgG1 and production of interleukin-1beta IL-1P and IL-6 by peritoneal macrophages. The suppression was strong and long-lasting. The clinical effects of liposomal DxM-P were dose-dependent for dosages between and mg kg. Single administration of 1 mg kg liposomal DxM-P and 3 X 1 mg kg of free DxM-P showed comparable effects consisting of a partial and .
