Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: bInterstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management. | Castelino and Varga Arthritis Research Therapy 2010 12 213 http content 12 4 213 REVIEW Interstitial lung disease in connective tissue diseases evolving concepts of pathogenesis and management Flavia V Castelino1 and John Varga2 Abstract Interstitial lung disease ILD is a challenging clinical entity associated with multiple connective tissue diseases and is a significant cause of morbidity and mortality. Effective therapies for connective tissue disease-associated interstitial lung disease CTD-ILD are still lacking. Multidisciplinary clinics dedicated to the early diagnosis and improved management of patients with CTD-ILD are now being established. There is rapid progress in understanding and identifying the effector cells the proinflammatory and profibrotic mediators and the pathways involved in the pathogenesis of CTD-ILD. Serum biomarkers may provide new insights as risk factors for pulmonary fibrosis and as measures of disease progression. Despite these recent advances the management of patients with CTD-ILD remains suboptimal. Further studies are therefore urgently needed to better understand these conditions and to develop effective therapeutic interventions. Introduction The term interstitial lung disease ILD is used to describe a heterogeneous group of parenchymal lung disorders that share common radiologic pathologic and clinical manifestations. ILD in its various guises can be asymptomatic but detected by high-resolution computed tomography HRCT of the chest or by pulmonary function tests. The fibrosing forms of ILD are often incurable and are associated with significant morbidity and mortality. ILD is subdivided into idiopathic interstitial pneumonia of which idiopathic pulmonary fibrosis IPF is Correspondence fcastelino@ Civision of Rheumatology Bulfinch-165 Massachusetts General Hospital Harvard Medical School 55 Fruit St Boston MA 02114 USA Full list of author information is available at the end of the article 2 .
