Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Antinuclear Antibodies (ANA) in Gordon Setters with Symmetrical Lupoid Onychodystrophy and Black Hair Follicular Dysplasia. | Acta vet. scand. 2001 42 323-329. Antinuclear Antibodies ANA in Gordon Setters with Symmetrical Lupoid Onychodystrophy and Black Hair Follicular Dysplasia By J. 0vreb0 Bohnhorst1 1. Hanssen2 and T. Moen1 department of Immunology and Bloodbank Trondheim University Hospital and 2Strinda Small Animal Clinic Trondheim Norway. 0vreb0 Bohnhorst J Hanssen I Moen T Antinuclear Antibodies ANA in Gordon setters with symmetrical lupoid onychodystrophy and black hair follicular dysplasia. Acta vet. scand. 2001 42 323-329. - Antinuclear antibodies ANA were demonstrated in 3 out of 10 Gordon setters with symmetrical lupoid onychodystrophy and in 5 out of 13 Gordon setters with black hair follicular dysplasia. Two dogs showed both symmetrical lupoid onychodystrophy and black hair follicular dysplasia and one of these was ANA positive. The results suggest that symmetrical lupoid onychodystrophy and black hair follicular dysplasia in the Gordon setter might be autoimmune diseases that are pathogenetically related which might indicate a common genetic predisposition. Introduction During the last decade there has been an increasing incidence of claw disease in dogs of the Gordon setter breed in Norway. The affected dogs show sudden pain and lameness and are observed to be licking 1 or more toes. By inspecting the feet it becomes evident that 1 or more and eventually all claws are detaching. Secondary bacterial infections are common. Histopathological studies of this phenomenon have not been conducted in Norway but Jonsson unpubl. 1996 found vacuolar alteration and degeneration of epidermal basal cells and acute and chronic inflammation and pigmentary incontinence in the dermis of the toes of an affected Swedish Gordon setter. These findings are in accordance with symmetrical lupoid onychodystrophy Scott et al. 1995 a . The dogs have been treated with antibiotics glucocorticoids zinc and fatty acid supplementation and the response has been recorded from poor to good Some dogs are put
